PATHOGENESIS OF LUMPY SKIN DISEASE IN INDIGENOUS CATTLE IN KAZAKHSTAN:  PATHOGENESIS OF LUMPY SKIN DISEASE IN INDIGENOUS CATTLE IN KAZAKHSTAN

Assylay Sarzhigitova; Issimov A.M.; Nissanova R.K.; Kemalova N.K.; Admanova G.B.

doi:10.52578/2305-9397-2025-2-2-184-198

Авторы

Assylay Sarzhigitova Актюбинский региональный университет имени К.Жубанова
Issimov A.M. «K. Zhubanov Aktobe Regional University», Aktobe, Ave. A.Moldagulova 34, 030000, Kazakhstan, https://orcid.org/0000-0001-6118-0576
Nissanova R.K. Kazakh Scientific Research Veterinary Institute LLP, Almaty, Rayimbek Ave 223, 050000, Kazakhstan https://orcid.org/0000-0003-0548-9207
Kemalova N.K. NJSC «K. Zhubanov Aktobe Regional University», Aktobe, Ave. A.Moldagulova 34, 030000, Kazakhstan https://orcid.org/0000-0002-0486-0054
Admanova G.B. NJSC «K. Zhubanov Aktobe Regional University», Aktobe, Ave. A.Moldagulova 34, 030000, Kazakhstan https://orcid.org/0009-0009-9568-0208

DOI:

https://doi.org/10.52578/2305-9397-2025-2-2-184-198

Ключевые слова:

Lumpy Skin Disease; LSDV; Experimental inoculation, Kazakhstan.

Аннотация

This study investigates the virulence properties and pathogenetic characteristics of the Kazakhstani
strain of LSDV (LSDV KZ-Kostanay-2018) in indigenous cattle under controlled conditions. Twelve
non-breed cattle were inoculated intradermally and monitored for clinical, pathological, and
immunological responses. Clinical signs, including fever, skin nodules, and lymphadenopathy, emerged
as early as day 5 post-infection (pi), with peak severity observed between days 11 and 14. Rapid
seroconversion was observed, with 100% of animals showing virus-neutralizing antibodies by day 13.
Pathological findings revealed extensive necrosis, thrombosis, and edema, with pronounced
damage in the spleen, lungs, and lymph nodes. Histological analyses identified widespread destructive
changes in the dermis and systemic tissues, consistent with highly aggressive disease progression. Viral
genome and replication were confirmed in blood, skin nodules, and lymph nodes, with peak viral loads
between days 11 and 14 pi. These results align with findings in Russian cattle infected with the
Saratov/2017 strain but demonstrate more rapid symptom onset and severe pathology, suggesting strain
specific virulence. These findings contribute to a deeper understanding of LSDV pathogenesis and
underscore the importance of regional adaptations in disease management.

Библиографические ссылки

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Наука и образование

PATHOGENESIS OF LUMPY SKIN DISEASE IN INDIGENOUS CATTLE IN KAZAKHSTAN