МЫСЫҚ ПАНЛЕЙКОПЕНИЯСЫНЫҢ ПАТОМОРФОЛОГИЯСЫ
МЫСЫҚ ПАНЛЕЙКОПЕНИЯСЫНЫҢ ПАТОМОРФОЛОГИЯСЫ
DOI:
https://doi.org/10.52578/2305-9397-2025-2-2-209-217%20Ключевые слова:
мысықтар, панлейкопения, ішек бүрлері, энтероциттер, крипталар, десквамация, некроз, денешіктер.Аннотация
АННОТАЦИЯ
Мақалада 2022-2023 жылдар аралығында, Қазақ Ұлттық аграрлық зерттеу университетінің, «Биологиялық қауіпсіздік» кафедрасына өлім себебін анықтау мақсатында әкелінген, табиғи жағдайда-контагиозды плевропневмониямен ауырған 3 жасқа дейінгі 7 бас – ешкі өлекселерінің ішкі мүшелерінде дамыған патологиялық морфологиялық өзгерістерінің зертеу нәтижелері берілген. Ауруға диагнозды кешенді түрде клиникалық белгілеріне, сойып зерттеу және зертханалық зерттеулер нәтижелері негізінде қойылды.
Ауырған ешкілер бір отарда қойлармен бірге бағылған. Бірақ, қойлар және сүт еметін лақтар арасында ауру тіркелмеген. Аурудың клиникалық белгілері, барлық ешкілерде бір типті көрініспен сипатталған: дене қызуы 41-42о С - қа дейін көтерілген, күйзелген, аз қозғалған, өріске шыққанда малдың соңында қалып қойған, тәбеті төмендеген, тыныс алуы қиындаған, жиі-жиі жөтелген, жөтелі құрғақ, ал кейбіреулерінде ылғалды болған. Барлық ауырған ешкілердің мұрын қуыстарынан кілегейлі-іріңді сұйық бөлінген. Кейбір ешкілердің қабағы ісініп, ол жерден кілегейлі - іріңді сұйық аққаны тіркелген. Ешкілер 5-8 күн ауырып, ауырған ешкілердің 80-90% өлген.
Ешкі өлекселері патологиялық анатомиялық сойып зерттеліп, ішкі мүшелері эвисцерация тәсілімен шығарылды. Гистологиялық зерттеуге өкпе, жүрек, бауыр, көкбауыр, лимфалық түйіндер, ішек кесекшелері алынды. Алынған кесекшелер бейтарапталған 10%-формалиннің судағы ерітіндісінде бекітіліп, парафинмен нығыздалды. Жұқа тілімдер жартылай автоматтандырылған микротом арқылы алынды және гематоксилин-эозинмен боялды. Дайын болған гистопрепараттар бинокулярлы жарық микроскоппен зерттелді.
Барлық сойып зерттелген ешкілер өкпесі фибринді некроздалатын пневмониямен, фибринді плевритпен, перикардитпен зақымдалғаны анықталды.
Библиографические ссылки
ӘДЕБИЕТТЕР ТІЗІМІ
Barrs, V. Feline Panleukopenia: A Re-emergent Disease. The Veterinary clinics of North
America // Small animal practice, - 2019.- 49(4), -651–670. https://doi.org/10.1016/j.cvsm.2019.02.006
Van Brussel, K. Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in
Australia // New Zealand and the United Arab Emirates. Viruses, 2019.-11(12), -Р.1155.
https://doi.org/10.3390/v11121155
Jenkins, E. Feline Parvovirus Seroprevalence Is High in Domestic Cats from Disease Outbreak
and Non-Outbreak Regions in Australia // Viruses, 2020. 12(3), 320.https://doi.org/10.3390/v12030320
Bergmann, M. Antibody response to feline panleukopenia virus vaccination in healthy adult cats
// Journal
of
feline
medicine
and
surgery, 2018.-
(12),
Р.
–1093.
https://doi.org/10.1177/1098612X17747740
Dall'Ara, P. Prevalence of serum antibody titres against feline panleukopenia, herpesvirus and
calicivirus infections in stray cats of Milan, Italy // Preventive veterinary medicine, 2019.167, 32–38.
https://doi.org/10.1016/j.prevetmed.2019.03.010
DiGangi, B. Prevalence of serum antibody titers against feline panleukopenia virus, feline
herpesvirus 1, and feline calicivirus in cats entering a Florida animal shelter // Journal of the American
Veterinary Medical Association, -2012.-P.241https://doi.org/10.2460/javma.241.10.1320
Soma, T. Anti-feline panleukopenia virus serum neutralizing antibody titer in domestic cats with
the negative or low hemagglutination inhibition antibody titer // The Journal of veterinary medical
science, 2019. 81(2), 252–255. https://doi.org/10.1292/jvms.18-0472
Egberink, H. Vaccination and Antibody Testing in Cats // Viruses, -2022.-14(8)-P.1602.
https://doi.org/10.3390/v14081602
Truyen, U. Feline panleukopenia virus: its interesting evolution and current problems in
immunoprophylaxis against a serious pathogen // Veterinary microbiology, -2013.- 165(1-2), -
P.29–32. https://doi.org/10.1016/j.vetmic.2013.02.005
Bergmann, M. Antibody response to feline panleukopenia virus vaccination in cats with
asymptomatic retrovirus infections: a pilot study // Journal of feline medicine and surgery,-2019. -21(12), -P.1094–1101. https://doi.org/10.1177/1098612X18816463
Barrs V. R. Feline Panleukopenia: A Re-emergent Disease // The Veterinary clinics of North
America. Small animal practice, 2019. 49(4), 651–670. https://doi.org/10.1016/j.cvsm.2019.02.006
Van Brussel, K. Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in
Australia, New Zealand and the United Arab Emirates // Viruses, 2020. -12-P. 1155.
Battilani, M. Genetic complexity and multiple infections with more Parvovirus species in
naturally infected cats // Veterinary research, 2011. 42(1), 43. https://doi.org/10.1186/1297-9716-42-43
Truyen, U. Feline panleukopenia virus: its interesting evolution and current problems in
immunoprophylaxis against a serious pathogen // Veterinary microbiology, 2013. 165(1-2), 29–32.
https://doi.org/10.1016/j.vetmic.2013.02.005
Wang, X. Low Intrahost and Interhost Genetic Diversity of Carnivore Protoparvovirus 1 in
Domestic Cats during a Feline Panleukopenia Outbreak // Viruses, -2022. -14(7), -P. 1412.
https://doi.org/10.3390/v14071412
Wang, T. Establishment of RPA-Cas12a-Based Fluorescence Assay for Rapid Detection of
Feline Parvovirus // Polish journal of microbiology, 2024. 73(1), -P. 39–48. https://doi.org/10.33073/pjm
-005
Kim, Y. Genetic Characterization of Feline Parvovirus Isolate Fe-P2 in Korean Cat and
Serological Evidence on Its Infection in Wild Leopard Cat and Asian Badger // Frontiers in veterinary
science,-2021. -8, -P.650866. https://doi.org/10.3389/fvets.2021.650866
Ahmed, N. Molecular analysis of partial VP-2 gene amplified from rectal swab samples of
diarrheic dogs in Pakistan confirms the circulation of canine parvovirus genetic variant CPV-2a and
detects sequences of feline panleukopenia virus (FPV) // Virology journal, -2018. -15(1), -P. 45.
https://doi.org/10.1186/s12985-018-0958-y
Rehme, T. Feline Panleukopenia Outbreaks and Risk Factors in Cats in Animal Shelters //
Viruses, 2022. 14(6), -P.1248. https://doi.org/10.3390/v14061248
Stuetzer, B. Feline parvovirus infection and associated diseases // Veterinary journal (London,
England: 1997), 2014. 201(2), 150–155. https://doi.org/10.1016/j.tvjl.2014.05.027
Liu, C. Identification and Genome Characterization of Novel Feline Parvovirus Strains Isolated
in
Shanghai, China //Current issues in molecular biology, 2023.- 45(4), -P.3628–3639.
https://doi.org/10.3390/cimb45040236
Wang, X. Low Intrahost and Interhost Genetic Diversity of Carnivore Protoparvovirus 1 in
Domestic Cats during a Feline Panleukopenia Outbreak // Viruses, 2022. -14(7),-P. 1412.
https://doi.org/10.3390/v14071412
Jenkins, E. Feline Parvovirus Seroprevalence Is High in Domestic Cats from Disease Outbreak
and Non-Outbreak Regions in Australia // Viruses, 2020. 12(3), 320. https://doi.org/10.3390/v12030320
Lamm, C. Parvovirus infection in domestic companion animals. The Veterinary clinics of North
America // Small animal practice, 2008. -38(4), -837–ix. https://doi.org/10.1016/j.cvsm.2008.03.008
Parrish C. Pathogenesis of feline panleukopenia virus and canine parvovirus // Bailliere's
clinical haematology, 1995. 8(1), 57–71. https://doi.org/10.1016/s0950-3536(05)80232-x
Li, Y. Virome of a Feline Outbreak of Diarrhea and Vomiting Includes Bocaviruses and a Novel
Chapparvovirus // Viruses, 2020. -12(5), -P.506. https://doi.org/10.3390/v12050506
Ma, H. Evaluation of feline mesenchymal stem cell susceptibility to feline viruses // Scientific
reports, 2024. 14(1), -P.18598. https://doi.org/10.1038/s41598-024-69343-1
REFERENCES
Barrs, V. Feline Panleukopenia: A Re-emergent Disease. The Veterinary clinics of North
America // Small animal practice,- 2019.- 49(4),-651–670. https://doi.org/10.1016/j.cvsm.2019.02.006
Van Brussel, K. Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in
Australia // New Zealand and the United Arab Emirates. Viruses, 2019.-11(12), -R.1155.
https://doi.org/10.3390/v11121155
Journal
Jenkins, E. Feline Parvovirus Seroprevalence Is High in Domestic Cats from Disease Outbreak
and Non-Outbreak Regions in Australia // Viruses, 2020. 12(3), 320. https://doi.org/10.3390/v12030320
Bergmann, M. Antibody response to feline panleukopenia virus vaccination in healthy adult cats
//
of
feline
medicine
https://doi.org/10.1177/1098612X17747740
and
surgery,
-
(12),
R.
–1093.
Dall'Ara, P. Prevalence of serum antibody titres against feline panleukopenia, herpesvirus and
calicivirus infections in stray cats of Milan, Italy // Preventive veterinary medicine, 2019.167, 32–38.
https://doi.org/10.1016/j.prevetmed.2019.03.010
DiGangi, B. Prevalence of serum antibody titers against feline panleukopenia virus, feline
herpesvirus 1, and feline calicivirus in cats entering a Florida animal shelter // Journal of the American
Veterinary Medical Association,-2012.-P.241https://doi.org/10.2460/javma.241.10.1320
Soma, T. Anti-feline panleukopenia virus serum neutralizing antibody titer in domestic cats with
the negative or low hemagglutination inhibition antibody titer // The Journal of veterinary medical
science, 2019. 81(2), 252–255. https://doi.org/10.1292/jvms.18-0472
Egberink, H. Vaccination and Antibody Testing in Cats // Viruses,-2022.-14(8)-P.1602.
https://doi.org/10.3390/v14081602
Truyen, U. Feline panleukopenia virus: its interesting evolution and current problems in
immunoprophylaxis against a serious pathogen // Veterinary microbiology,-2013.- 165(1-2), -P.29–32.
https://doi.org/10.1016/j.vetmic.2013.02.005
Bergmann, M. Antibody response to feline panleukopenia virus vaccination in cats with
asymptomatic retrovirus infections: a pilot study // Journal of feline medicine and surgery,-2019. -21(12), -P.1094–1101. https://doi.org/10.1177/1098612X18816463
Barrs V. R. Feline Panleukopenia: A Re-emergent Disease // The Veterinary clinics of North
America. Small animal practice, 2019. 49(4), 651–670. https://doi.org/10.1016/j.cvsm.2019.02.006
Van Brussel, K. Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in
Australia, New Zealand and the United Arab Emirates // Viruses, 2020. -12-P. 1155.
Battilani, M. Genetic complexity and multiple infections with more Parvovirus species in
naturally infected cats // Veterinary research, 2011. 42(1), 43. https://doi.org/10.1186/1297-9716-42-43
Truyen, U. Feline panleukopenia virus: its interesting evolution and current problems in
immunoprophylaxis against a serious pathogen // Veterinary microbiology, 2013. 165(1-2), 29–32.
https://doi.org/10.1016/j.vetmic.2013.02.005
Wang, X. Low Intrahost and Interhost Genetic Diversity of Carnivore Protoparvovirus 1 in
Domestic Cats during a Feline Panleukopenia Outbreak // Viruses,-2022. -14(7),-P. 1412.
https://doi.org/10.3390/v14071412
Wang, T. Establishment of RPA-Cas12a-Based Fluorescence Assay for Rapid Detection of
Feline Parvovirus // Polish journal of microbiology, 2024. 73(1),-P. 39–48. https://doi.org/10.33073/pjm
-005
Kim, Y. Genetic Characterization of Feline Parvovirus Isolate Fe-P2 in Korean Cat and
Serological Evidence on Its Infection in Wild Leopard Cat and Asian Badger // Frontiers in veterinary
science,-2021. -8, -P.650866. https://doi.org/10.3389/fvets.2021.650866
Ahmed, N. Molecular analysis of partial VP-2 gene amplified from rectal swab samples of
diarrheic dogs in Pakistan confirms the circulation of canine parvovirus genetic variant CPV-2a and
detects sequences of feline panleukopenia virus (FPV) // Virology journal,-2018. -15(1),-P. 45.
https://doi.org/10.1186/s12985-018-0958-y
Rehme, T. Feline Panleukopenia Outbreaks and Risk Factors in Cats in Animal Shelters //
Viruses, 2022. 14(6), -P.1248. https://doi.org/10.3390/v14061248
Stuetzer, B. Feline parvovirus infection and associated diseases // Veterinary journal (London,
England : 1997), 2014. 201(2), 150–155. https://doi.org/10.1016/j.tvjl.2014.05.027
Liu, C. Identification and Genome Characterization of Novel Feline Parvovirus Strains Isolated
in
Shanghai, China //Current issues in molecular biology, 2023.- 45(4), -P.3628–3639.
https://doi.org/10.3390/cimb45040236
Wang, X. Low Intrahost and Interhost Genetic Diversity of Carnivore Protoparvovirus 1 in
Domestic Cats during a Feline Panleukopenia Outbreak // Viruses, 2022. -14(7),-P. 1412.
https://doi.org/10.3390/v14071412
Jenkins, E. Feline Parvovirus Seroprevalence Is High in Domestic Cats from Disease Outbreak
and Non-Outbreak Regions in Australia // Viruses, 2020. 12(3), 320. https://doi.org/10.3390/v12030320
Lamm, C. Parvovirus infection in domestic companion animals. The Veterinary clinics of North
America // Small animal practice, 2008. -38(4), -837–ix. https://doi.org/10.1016/j.cvsm.2008.03.008
Parrish C. Pathogenesis of feline panleukopenia virus and canine parvovirus // Bailliere's
clinical haematology, 1995. 8(1), 57–71. https://doi.org/10.1016/s0950-3536(05)80232-x
Li, Y. Virome of a Feline Outbreak of Diarrhea and Vomiting Includes Bocaviruses and a Novel
Chapparvovirus // Viruses, 2020. -12(5), -P.506. https://doi.org/10.3390/v12050506
Ma, H. Evaluation of feline mesenchymal stem cell susceptibility to feline viruses // Scientific
reports, 2024. 14(1), -P.18598. https://doi.org/10.1038/s41598-024-69343-1