PASTEURELLOSIS IN CATTLE: CLINICAL MANIFESTATIONS AND PATHOLOGICAL CHANGES
DOI:
https://doi.org/10.52578/2305-9397-2025-4-1-114-121Ключевые слова:
Key words: pasteurellosis, cattle, Pasteurella multocida, pathological changes, septic formАннотация
Pasteurellosis in cattle remains one of the most important bacterial infections, causing significant economic losses due to high mortality rates, reduced productivity, and the costs of treatment and preventive measures. The present study was conducted in 2022 in the Beskaragai district of Abai region (Kazakhstan) with the aim of describing the clinical course and pathological manifestations of pasteurellosis in cattle under natural farm conditions.
The material for the study consisted of 20 carcasses of cattle aged 6–13 years, six of which exhibited clinical signs consistent with pasteurellosis. Post-mortem examinations were performed using the method of complete evisceration developed by Professor G. V. Shor. Pathological samples were collected during necropsy and subjected to laboratory analysis, which confirmed the presence of Pasteurella multocida in all cases.
Clinically, affected cattle demonstrated typical signs of the septicemic form of pasteurellosis. These included severe depression, anorexia, hyperthermia (up to 41.3 °C), absence of rumination, and dryness of the nasal planum. Gastrointestinal dysfunction manifested as hypomotility and constipation within the first 24 hours, followed by diarrhea with mucus and blood on the second day.
Pathological findings revealed extensive serous edema of subcutaneous and intermuscular tissues, particularly in the throat, intermaxillary space, and brisket. Hemorrhagic diathesis was noted on serous membranes, including the pleura and epicardium, whereas parenchymal petechiae were absent. Lymph nodes showed acute serous lymphadenitis, being enlarged, hyperemic, and tense on incision. The lungs exhibited acute bilateral serous-catarrhal bronchopneumonia, and in 50% of cases the lesions had a hemorrhagic character. Notably, fibrinous inflammation, often associated with pasteurellosis, was not observed.
The results confirm that the septicemic form of pasteurellosis in cattle is characterized by a complex of systemic clinical and morphological changes.
Библиографические ссылки
Harper M., Boyce J. D., Adler B. Pasteurella multocida pathogenesis: 125 years after Pasteur // FEMS Microbiology Letters. – 2006. – Vol. 265, № 1. – P. 1–10. – DOI: 10.1111/j.1574-6968.2006.tb08941.x.
Quinn P. J., Markey B. K., Leonard F. C., Hartigan P., Fanning S., Fitzpatrick E. Veterinary Microbiology and Microbial Disease. – 2nd ed. – Wiley-Blackwell, 2011.
Wilson B. A., Ho M. Pasteurella multocida: from zoonosis to cellular microbiology // Clinical Microbiology Reviews. – 2013. – Vol. 26, № 3. – P. 631–655. – DOI: 10.1128/CMR.00024-13.
Abdybekova A. M., Zhaksylykova A. A., Kushaliyev K. Z. [et al.] A survey of the parasites of Ural saiga antelopes and Turkmenian kulans of Kazakhstan // International Journal for Parasitology: Parasites and Wildlife. – 2023. – Vol. 21. – P. 232–236. – DOI: 10.1016/j.ijppaw.2023.06.006.
Shivachandra S. B., Viswas K. N., Kumar A. A. A review on haemorrhagic septicaemia in cattle and buffalo // Animal Health Research Reviews. – 2011. – Vol. 12, № 1. – P. 67–82. – DOI: 10.1017/S146625231100003X.
Dziva F., Muhairwa A. P. Pasteurella multocida: the causative agent of haemorrhagic septicaemia in cattle and buffalo // Veterinary Research. – 2008. – Vol. 39, № 5. – P. 11. – DOI: 10.1051/vetres:2008012.
Vlasenko A. N., Chumachenko V. V., Nazarenko S. N. Patogenez pasterelljoza molodnjaka KRS // Veterinarija Kubani. – 2012. – № 3. – S. 12–15.
Kondrashkina N. G., Sedov V. A., Hakhin A. A. Pasterelljoz sel'skohozjajstvennyh zhivotnyh. – M.: Kolos, 2001.
Boyce J. D., Chung J. Y., Adler B. Pasteurella multocida capsule: composition, function and genetics // Journal of Biotechnology. – 2010. – Vol. 144, № 1. – P. 1–10. – DOI: 10.1016/j.jbiotec.2009.09.001.
Ewers C., Lübke-Becker A., Wieler L. H. [et al.] Virulence genotypes of Pasteurella multocida strains isolated from different hosts with various disease status // Veterinary Microbiology. – 2006. – Vol. 114, № 3–4. – P. 304–317. – DOI: 10.1016/j.vetmic.2005.11.055.
Hodgson J. C., Finn A., Field S. L., Finlayson J., Donachie W. Comparative virulence of Pasteurella multocida isolates in calves // Microbial Pathogenesis. – 2005. – Vol. 39, № 5–6. – P. 177–185. – DOI: 10.1016/j.micpath.2005.08.003.
Shor G. V. Rukovodstvo po vskrytiju trupov. – M.: Medgiz, 1937.
Popov V. S., Vasil’ev A. I., Kapustin A. V. Patologicheskaja anatomija sel'skohozjajstvennyh zhivotnyh. – M.: Kolos, 1985.
Biberstein E. L., Hirsh D. C. Pasteurella // In: Veterinary Microbiology. – Blackwell Science, 1999. – P. 135–144.
Quinn P. J., Markey B. K., Leonard F. C. [et al.] Veterinary Microbiology and Microbial Disease. – 2nd ed. – Wiley-Blackwell, 2011.
Dziva F., Muhairwa A. P. Pasteurella multocida: the causative agent of haemorrhagic septicaemia in cattle and buffalo // Veterinary Research. – 2008. – Vol. 39, № 5. – P. 11. – DOI: 10.1051/vetres:2008012.
Shivachandra S. B., Viswas K. N., Kumar A. A. A review on haemorrhagic septicaemia in cattle and buffalo // Animal Health Research Reviews. – 2011. – Vol. 12, № 1. – P. 67–82. – DOI: 10.1017/S146625231100003X.
Vlasenko A. N., Chumachenko V. V., Nazarenko S. N. Patogenez pasterelljoza molodnjaka KRS // Veterinarija Kubani. – 2012. – № 3. – S. 12–15.
Terent’ev V. P., Ivanov V. N., Kudrjavcev A. A. Differencial'naja diagnostika bakterial'nyh infekcij teljat // Veterinarija. – 2015. – № 11. – S. 18–21.
Wilson B. A., Ho M. Pasteurella multocida: from zoonosis to cellular microbiology // Clinical Microbiology Reviews. – 2013. – Vol. 26, № 3. – P. 631–655. – DOI: 10.1128/CMR.00024-13.
Abdybekova A. M., Zhaksylykova A. A., Kushaliyev K. Z. [et al.] A survey of the parasites of Ural saiga antelopes and Turkmenian kulans of Kazakhstan // International Journal for Parasitology: Parasites and Wildlife. – 2023. – Vol. 21. – P. 232–236. – DOI: 10.1016/j.ijppaw.2023.06.006.
