VETERINARY PATHOLOGY OF ORGANOPHOSPHATE TOXICITY IN DOGS
VETERINARY PATHOLOGY OF ORGANOPHOSPHATE TOXICITY IN DOGS
DOI:
https://doi.org/10.52578/2305-9397-2025-4-1-10-17Ключевые слова:
organophosphates, dog, pathological changes, histology, poisoningАннотация
Organophosphorus compounds are widely used in agriculture as insecticides and acaricides. However, their improper use or violation of safety regulations can lead to animal poisoning. This study is devoted to the investigation of pathological and histopathological changes in dog that died as a result of acute organophosphorus poisoning.
The object of the study was the carcass of a dog submitted for veterinary-sanitary examination. The necropsy revealed typical macroscopic signs: pronounced rigor mortis, cyanosis of the skin and mucous membranes, hyperemia and pulmonary edema, multiple hemorrhages under serous membranes, in muscles and mucous membranes, as well as erosive and ulcerative lesions in the gastrointestinal tract. The liver, kidneys, and heart also showed signs of dystrophy and congestion.
Histological examination confirmed the presence of edema, hemorrhages, and dystrophic and necrotic changes in the tissues of the lungs, liver, kidneys, and myocardium. Inflammatory and necrotic processes were observed in the stomach and intestines. The identified morphological changes correlate with the known mechanism of toxic action of organophosphorus compounds, which is based on the inhibition of acetylcholinesterase and disruption of vital organ functions.
The obtained results can be used in veterinary diagnostics, forensic examinations, and in the development of preventive measures and the safe application of organophosphorus compounds in animal husbandry.
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